InsideOut Institute is Australia's national leader in eating disorder research. Our work spans clinical trials, digital innovation, and translation into real-world practice. Through global research partnerships, we are advancing knowledge to improve prevention, early intervention, and treatment for eating disorders, with the ultimate goal of finding a cure.
Understanding the neurobiology to improve outcomes for people with EDs
The TailorED study tests innovative interventions for people with Bulimia Nervosa or Binge Eating Disorder who don't respond well to standard cognitive behavioural therapy, comparing personalised care with brain stimulation (TMS). This stepped-care approach aims to optimise treatment outcomes, reduce costs and waiting times, and provide evidence for tailoring care based on individual treatment response.
This study applies nutritional geometry to food diary records from 200 people with Binge Eating Disorder or Bulimia Nervosa to investigate whether insufficient protein intake drives overconsumption and loss of dietary control.
EDGI is a world-first genome-wide association study conducted in collaboration with QIMR Berghofer and international researchers. It aims to identify the hundreds of genes contributing to Anorexia Nervosa, Bulimia Nervosa, Binge Eating Disorder, and ARFID, to enable more targeted, personalised interventions and earlier detection in high-risk groups.
The My Diet Study is the first longitudinal, observational investigation of self-directed dieting patterns in young people aged 16-25, combining in-depth psychological and biological data to understand factors impacting dieting experiences. By examining natural dieting habits before eating disorders emerge, the research aims to identify biomarkers for risk, inform safety frameworks for young people's dieting, and establish evidence-based guidance for diet-based lifestyle interventions.
This trial evaluates the safety, feasibility, and preliminary efficacy of psilocybin-assisted psychotherapy for individuals with treatment-resistant anorexia nervosa who have not responded to standard evidence-based interventions.
This study investigates brain and hormonal responses to real-time food consumption decisions in individuals with anorexia nervosa using brain imaging and biomarker analysis. The research aims to identify biological drivers of restrictive eating and inform development of novel treatment targets.
This study examines who is using GLP-1 agonists (Ozempic, Wegovy, Mounjaro) and their experiences, particularly regarding physical and mental health outcomes, side effects, and associations with disordered eating. Through surveys and interviews with users aged 18+, the research aims to identify the benefits and harms of these medications and provide insights into their real-world effects on health and wellbeing.
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