This study looked at how lisdexamfetamine dimesylate (LDX) affects the brain in people with binge eating disorder. After treatment, people showed brain changes that went along with feeling and functioning better, suggesting the medicine may help by shifting how the brain handles appetite, reward, and self‑control.
Aims
This is a comprehensive data-driven investigation of brain functional connectivity changes underlying the therapeutic action of lisdexamfetamine dimesylate (LDX) in patients with Binge Eating Disorder (BED). Resting-state functional magnetic resonance imaging (MRI) was used to probe changes in the brain before and after treatment, and to explore correlated changes in clinical measures. The results showed widespread neural changes that were associated with improvements in clinical outcomes. These connections were not distinct from control participants at pre-treatment, but they differed from control participants following LDX treatment. Pre-treatment connectivity did not predict treatment response.
Background
Speculation exists as to whether LDX acts on the functional connectivity (FC) of brain networks that modulate appetite, reward, or inhibitory control in BED. The study seeks better insights into the action of LDX, which may help to guide the development of more targeted therapeutics, as well as identify who will benefit most from this medication.
Functional Connectivity Mechanisms Underlying Symptom Reduction Following Lisdexamfetamine Treatment in Binge-Eating Disorder: A Clinical Trial.
Griffiths, K. R., Breukelaar, I. A., Harvie, G., Yang, J., Foster, S. L., Harris, A. W., Clarke, S., Hay, P. J., Touyz, S., Korgaonkar, M. S., & Kohn, M. R.
Biological Psychiatry Global Open Science.
4(1), 317–325.
Understanding the neural mechanisms of lisdexamfetamine dimesylate (LDX) pharmacotherapy in Binge Eating Disorder (BED): A study protocol
Griffiths, K. R., Yang, J., Touyz, S. W., Hay, P. J., Clarke, S. D., Korgaonkar, M. S., Gomes, L., Anderson, G., Foster, S., & Kohn, M. R.
Journal of Eating Disorders.
7, 23.
Exploring bi-directional impacts of Lisdexamfetamine dimesylate on psychological comorbidities and quality of life in people with Binge Eating Disorder
Griffiths, K. R., Boulet, S., Barakat, S., Touyz, S., Hay, P., Maguire, S., & Kohn, M. R.
Journal of Eating Disorders.
12(1), 80.
Impulsivity and Its Relationship With Lisdexamfetamine Dimesylate Treatment in Binge Eating Disorder
Griffiths, K. R., Aparício, L., Braund, T. A., Yang, J., Harvie, G., Harris, A., Hay, P. J., Touyz, S., & Kohn, M. R.
Frontiers in Psychology.
12, 716010.
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